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ea0063p611 | Diabetes, Obesity and Metabolism 2 | ECE2019

Prenatal metformin treatment in obese rats: Evaluation of liver norepinephrine and lipogenic enzymes in offspring

Valero Viviana , Fernandois Daniela , Alvarez Daniela , Cruz Gonzalo

Maternal obesity during pregnancy is associated with several metabolic impairments in offspring, some of them evidenced from early infancy. Some reports have demonstrated that offspring of obese rats, whose obesity was induced by high fat diet consumption, have an increase sympathetic tone and increased norepinephrine (NE) content in kidney, liver and ovary. We recently reported that maternal administration of metformin prevents the increase in ovarian NE in offspring when the...

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ea0081ep439 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Time restricted feeding 16/8 improves metabolic parameters and fatty liver in obese mice

Astudillo Camila , Acevedo Paula , Ceballo Karina , Julio Marcela , Dorfman Mauricio , Cruz Gonzalo

Obesity is a major health problem that is crucial in the pathogenesis of diabetes mellitus, cardiovascular diseases, and some types of cancer. Intermittent fasting is an eating pattern in which periods of fasting, lasting from 12 up to 36h, are alternated with periods of eating. Time restricted feeding (TRF) 16/8 is a type of intermittent fasting that is being used to lose weight and for treating metabolic disorders. Several studies in humans have shown a slight effect of TRF ...

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ea0041gp147 | Paediatric Endocrinology & Development | ECE2016

Prenatal metformin treatment prevents estradiol increase and partially improves ovarian function in offspring of obese mothers

Alvarez Daniela , Olguin Sofia , Ceballo Karina , Martinez Jonathan , Cerda Tania , Fernandois Daniela , Cruz Gonzalo

Obesity epidemic is one of the major concerns in the world. Worryingly, a high percentage of pregnant women have obesity, which could imply several consequences. Maternal obesity leads to different abnormalities in pregnancy and delivery. In addition, recent studies show that the offspring of obese mothers has an increased probability to suffer cardiovascular, metabolic and reproductive diseases. We have previously demonstrated that exposure to a high fat diet is related to ob...

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ePoster

ea0037ep157 | Reproduction, endocrine disruptors and signalling | ECE2015

Maternal obesity in pregnant rats is associated to increased levels of oestradiol during early postnatal life and altered ovarian follicular development in the offspring

Reyes Aldo , Ramirez Luisa , Ambrosetti Valery , Guerra Marcelo , Alvarez Daniela , Olguin Sofia , Fernandois Daniela , Sotomayor-Zarate Ramon , Cruz Gonzalo

Obesity during gestation has been related to predisposition to endocrine and metabolic diseases in the offspring. Regarding reproductive effects, an increase in BMI in pregnant mothers is associated with precocious puberty in their offspring. This has been replicated in animal models of high fat diet (HFD) administration to mothers. Also, gestational obesity has been associated to higher susceptibility to developing breast cancer in the offspring. As both precocious puberty an...